An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

IANNUZZI, Michael C.

1 entries
  • 13568

Identification of the cystic fibrosis gene: Chromosome walking and jumping.

Science, 245, 1059-1065, 1989.

Utilizing the chromosome "walking and and jumping" technique developed by Collins, the authors showed how they cloned the cystic fibrosis locus on the basis of its chromosomal location without the benefit of genomic rearrangements. They showed that the CF gene spans approximately 250,000 base pairs of genomic DNA. This was the first gene for a human disease discovered without a known protein sequence.

Order of authorship in the original publication: Rommens, Iannuzzi, et al..., Riordan, Tsui, Collins.

(Thanks to Juan Weiss for this reference and its interpretation.)



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Genomics, GENETICS / HEREDITY › GENETIC DISORDERS › Cystic Fibrosis