An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

JOYCE, Lyle D.

2 entries
  • 12230

The artificial heart.

Ciba Symp., 35, No. 6, 1983.

First published report on the first successful "permanent" artificial heart operation, in which DeVries implanted the Jarvik-7 artifical heart in Barney Clark, a patient affected with end-stage congestive heart failure. The surgery took place on December 2, 1982; Clark lived for 112 days after the surgery. The Ciba Symposia issue was extensively illustrated by Frank Netter,



Subjects: CARDIOVASCULAR (Cardiac) SURGERY › Heart Transplants › Artificial Heart Transplant
  • 12231

Clinical use of the total artificial heart.

New Eng. J. Med., 310, 273-278, 1984.

"Abstract

"We report here our first experience with the use of a total artificial heart in a human being. The heart [Jarvik-7] was developed at the University of Utah, and the patient was a 61-year-old man with chronic congestive heart failure due to primary cardiomyopathy, who also had chronic obstructive pulmonary disease.

"Except for dysfunction of the prosthetic mitral valve, which required replacement of the left-heart prosthesis on the 13th postoperative day, the artificial heart functioned well for the entire postoperative course of 112 days. The mean blood pressure was 84±8 mm Hg, and cardiac output was generally maintained at 6.7±0.8 liters per minute for the right heart and 7.5±0.8 for the left, resulting in postoperative diuresis and relief of congestive failure.

"The postoperative course was complicated by recurrent pulmonary insufficiency, several episodes of acute renal failure, episodes of fever of unidentified cause (necessitating multiple courses of antibiotics), hemorrhagic complications of anticoagulation, and one generalized seizure of uncertain cause.

"On the 92nd postoperative day, the patient had diarrhea and vomiting, leading to aspiration pneumonia and sepsis. Death occurred on the 112th day, preceded by progressive renal failure and refractory hypotension, despite maintenance of cardiac output. Autopsy revealed extensive pseudomembranous colitis, acute tubular necrosis, peritoneal and pleural effusion, centrilobular emphysema, and chronic bronchitis with fibrosis and bronchiectasis. The artificial heart system was intact and uninvolved by thrombosis or infectious processes.

"This experience should encourage further clinical trials with the artificial heart, but we emphasize that the procedure is still highly experimental. Further experience, development, and discussion will be required before more general application of the device can be recommended. (N Engl J Med 1984; 310:273–8.)"



Subjects: CARDIOVASCULAR (Cardiac) SURGERY › Heart Transplants › Artificial Heart Transplant