An Interactive Annotated World Bibliography of Printed and Digital Works in the History of Medicine and the Life Sciences from Circa 2000 BCE to 2022 by Fielding H. Garrison (1870-1935), Leslie T. Morton (1907-2004), and Jeremy M. Norman (1945- ) Traditionally Known as “Garrison-Morton”

15961 entries, 13944 authors and 1935 subjects. Updated: March 22, 2024

VINOGRAD, Jerome

1 entries
  • 13963

The twisted circular form of polyoma viral DNA.

Proc. Nat. Acad. Sci. (USA), 53, 1104-1111, 1965.

Discovery of DNA supercoiling. DNA supercoiling refers to the amount of twist in a particular DNA strand, which determines the amount of strain on it. A given strand may be "positively supercoiled" or "negatively supercoiled" (more or less tightly wound). The amount of a strand’s supercoiling affects a number of biological processes, such as compacting DNA and regulating access to the genetic code (which strongly affects DNA metabolism and possibly gene expression). With R. Radloff, R. Watson & P. Laipis. Digital facsimile from PubMedCentral at this link. See also, Jacob Lebowitz, "Through the looking glass: The discovery of supercoiled DNA," Trends in Biochemical Sciences, 15 (1990) 202-207.



Subjects: BIOLOGY › MOLECULAR BIOLOGY › Nucleic Acids